Hypoxic conditioned medium from mesenchymal stem cells promotes lymphangiogenesis by regulation of mitochondrial-related proteins
Identifieur interne : 000F99 ( Main/Exploration ); précédent : 000F98; suivant : 001000Hypoxic conditioned medium from mesenchymal stem cells promotes lymphangiogenesis by regulation of mitochondrial-related proteins
Auteurs : Chang Youn Lee [Corée du Sud] ; Jin Young Kang [Corée du Sud] ; Soyeon Lim ; Onju Ham [Corée du Sud] ; Woochul Chang [Corée du Sud] ; Dae-Hyun JangSource :
- Stem Cell Research & Therapy [ 1757-6512 ] ; 2016.
Descripteurs français
- KwdFr :
- Agents angiogéniques (pharmacologie), Animaux, Cellules endothéliales (physiologie), Cellules stromales mésenchymateuses (sécrétion), Humains, Hypoxie cellulaire, Lymphangiogenèse, Milieux de culture conditionnés (), Prolifération cellulaire, Protéines mitochondriales (physiologie), Régénération, Souris de lignée BALB C, Vaisseaux lymphatiques (physiologie).
- MESH :
- pharmacologie : Agents angiogéniques.
- physiologie : Cellules endothéliales, Protéines mitochondriales, Vaisseaux lymphatiques.
- sécrétion : Cellules stromales mésenchymateuses.
- Animaux, Humains, Hypoxie cellulaire, Lymphangiogenèse, Milieux de culture conditionnés, Prolifération cellulaire, Régénération, Souris de lignée BALB C.
English descriptors
- KwdEn :
- Angiogenesis Inducing Agents (pharmacology), Animals, Cell Hypoxia, Cell Proliferation, Culture Media, Conditioned (chemistry), Endothelial Cells (physiology), Humans, Lymphangiogenesis, Lymphatic Vessels (physiology), Mesenchymal Stromal Cells (secretion), Mice, Inbred BALB C, Mitochondrial Proteins (physiology), Regeneration.
- MESH :
- chemical , chemistry : Culture Media, Conditioned.
- chemical , pharmacology : Angiogenesis Inducing Agents.
- physiology : Endothelial Cells, Lymphatic Vessels, Mitochondrial Proteins.
- secretion : Mesenchymal Stromal Cells.
- Animals, Cell Hypoxia, Cell Proliferation, Humans, Lymphangiogenesis, Mice, Inbred BALB C, Regeneration.
Abstract
Recently, cell-based therapeutic lymphangiogenesis has emerged and provided hope for lymphatic regeneration. Previous studies have demonstrated that secretomes of mesenchymal stem cells (MSCs) facilitate the regeneration of various damaged tissues. This study was conducted to evaluate the lymphangiogenic potential of hypoxic conditioned media (HCM) from MSCs.
To investigate the effects of MSC-secreted factors in starved human lymphatic endothelial cells (hLEC), hLECs were treated with endothelial basal medium (EBM)-2 (control), normoxic conditioned media (NCM), or HCM
MSCs expressed lymphangiogenic factors including EGF, FGF2, HGF, IGF-1, and VEGF-A and -C. hLECs were treated with each medium. hLEC proliferation, migration, and tube formation were improved under HCM compared with NCM. Moreover, expression of mitochondrial-related factors, MFN1and 2, were improved in HCM-treated hLECs. Lymphedema mice injected with HCM showed markedly decreased lymphedema via increased lymphatic vessel formation when compared with EBM-2- or NCM-treated mice.
This study suggested that HCM from MSCs contain high levels of secreted lymphangiogenic factors and promote lymphangiogenesis by regulating mitochondrial-related factors. Thus, treatment with HCM may be a therapeutic strategy for lymphedema.
Url:
DOI: 10.1186/s13287-016-0296-1
PubMed: 26968383
PubMed Central: 4788827
Affiliations:
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Le document en format XML
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<term>Cell Hypoxia</term>
<term>Cell Proliferation</term>
<term>Culture Media, Conditioned (chemistry)</term>
<term>Endothelial Cells (physiology)</term>
<term>Humans</term>
<term>Lymphangiogenesis</term>
<term>Lymphatic Vessels (physiology)</term>
<term>Mesenchymal Stromal Cells (secretion)</term>
<term>Mice, Inbred BALB C</term>
<term>Mitochondrial Proteins (physiology)</term>
<term>Regeneration</term>
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<term>Animaux</term>
<term>Cellules endothéliales (physiologie)</term>
<term>Cellules stromales mésenchymateuses (sécrétion)</term>
<term>Humains</term>
<term>Hypoxie cellulaire</term>
<term>Lymphangiogenèse</term>
<term>Milieux de culture conditionnés ()</term>
<term>Prolifération cellulaire</term>
<term>Protéines mitochondriales (physiologie)</term>
<term>Régénération</term>
<term>Souris de lignée BALB C</term>
<term>Vaisseaux lymphatiques (physiologie)</term>
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<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Culture Media, Conditioned</term>
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<term>Protéines mitochondriales</term>
<term>Vaisseaux lymphatiques</term>
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<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Endothelial Cells</term>
<term>Lymphatic Vessels</term>
<term>Mitochondrial Proteins</term>
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<term>Cell Hypoxia</term>
<term>Cell Proliferation</term>
<term>Humans</term>
<term>Lymphangiogenesis</term>
<term>Mice, Inbred BALB C</term>
<term>Regeneration</term>
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<term>Humains</term>
<term>Hypoxie cellulaire</term>
<term>Lymphangiogenèse</term>
<term>Milieux de culture conditionnés</term>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Recently, cell-based therapeutic lymphangiogenesis has emerged and provided hope for lymphatic regeneration. Previous studies have demonstrated that secretomes of mesenchymal stem cells (MSCs) facilitate the regeneration of various damaged tissues. This study was conducted to evaluate the lymphangiogenic potential of hypoxic conditioned media (HCM) from MSCs.</p>
</sec>
<sec><title>Methods</title>
<p>To investigate the effects of MSC-secreted factors in starved human lymphatic endothelial cells (hLEC), hLECs were treated with endothelial basal medium (EBM)-2 (control), normoxic conditioned media (NCM), or HCM <italic>in vitro</italic>
and <italic>in vivo.</italic>
</p>
</sec>
<sec><title>Results</title>
<p>MSCs expressed lymphangiogenic factors including EGF, FGF2, HGF, IGF-1, and VEGF-A and -C. hLECs were treated with each medium. hLEC proliferation, migration, and tube formation were improved under HCM compared with NCM. Moreover, expression of mitochondrial-related factors, MFN1and 2, were improved in HCM-treated hLECs. Lymphedema mice injected with HCM showed markedly decreased lymphedema via increased lymphatic vessel formation when compared with EBM-2- or NCM-treated mice.</p>
</sec>
<sec><title>Conclusions</title>
<p>This study suggested that HCM from MSCs contain high levels of secreted lymphangiogenic factors and promote lymphangiogenesis by regulating mitochondrial-related factors. Thus, treatment with HCM may be a therapeutic strategy for lymphedema.</p>
</sec>
</div>
</front>
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</back>
</TEI>
<affiliations><list><country><li>Corée du Sud</li>
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<region><li>Région capitale de Séoul</li>
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<settlement><li>Séoul</li>
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<tree><noCountry><name sortKey="Jang, Dae Hyun" sort="Jang, Dae Hyun" uniqKey="Jang D" first="Dae-Hyun" last="Jang">Dae-Hyun Jang</name>
<name sortKey="Lim, Soyeon" sort="Lim, Soyeon" uniqKey="Lim S" first="Soyeon" last="Lim">Soyeon Lim</name>
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<name sortKey="Ham, Onju" sort="Ham, Onju" uniqKey="Ham O" first="Onju" last="Ham">Onju Ham</name>
<name sortKey="Kang, Jin Young" sort="Kang, Jin Young" uniqKey="Kang J" first="Jin Young" last="Kang">Jin Young Kang</name>
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</tree>
</affiliations>
</record>
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